Consequences of psoriasis

How does psoriasis develop? Is this complication an inherited disease and has a genetic background? Do environmental factors play a role in its development or not? Among the problems that this skin complication causes for our health, we can mention obesity and diabetes. Type 2, Crohn’s disease and inflammation of the intestine, osteoporosis, depression.

Psoriasis is a chronic skin disease that causes skin cells to accumulate rapidly on the surface of the skin, leading to thickening of the skin, the formation of silver scales, or red, dry, itchy spots. Apart from this, this disease can also increase the risk of a number of your health problems, some of which are life-threatening, and here are some of them.
Obesity and type 2 diabetes
The risk of developing psoriasis in people with type 2 diabetes is 50 percent higher than in people without diabetes, and this risk is twice as high in obese people with a body mass index of more than 35 than in people of normal weight. “Environmental factors are also involved,” says one researcher. “Like smoking or being overweight.”
Research shows that there is a clear link between inflamed skin and weakened bones. After performing CT scans on 100 patients with psoriasis, the researchers found that most of them had bone weakness problems with an increase in a substance called the cytokine IL-17A; An immune system protein that blocks the body’s ossification activity.
Crohn’s disease and inflammatory bowel disease
About 10% of women with psoriasis develop inflammatory bowel disease, such as Crohn’s disease or inflammatory bowel disease. “We think all of these diseases have the same genetic cause, and that is the cleavage of two cytokinins – interleukin 12 and interleukin 23 – that will help regulate the body’s immune system,” said one researcher.
About 16.5% of patients with psoriasis also suffer from a depressive crisis, and if you have psoriasis, your risk of developing depression is doubled. This is one of the conditions that it is not known whether it was chicken or egg first: Can it be said that people with psoriasis suffer from depression because they do not have a good sense of skin blemishes? Or is there still some undiscovered genetic variation at work that makes you vulnerable to both conditions? Whatever the cause, it is best to tell your doctor if you have any symptoms of depression.
Source: Al-Doctor

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