Genetic factors of infertility

In this article, we have discussed all the factors and causes of infertility in men and we have pointed out the treatment methods for each of them.

Dr. Ketayoun Bergis stated that one of the genetic causes that causes a decrease in fertility in men is the removal of the Y chromosome, which, in addition to reducing fertility and the need for advanced assisted reproductive procedures, is also genetically transmitted to the next generation of a person, and said: Investigating the history of infertility In the family, it is recorded in the history of the patient.

He said: Another genetic cause of Klinefelter syndrome is the presence of an extra X chromosome in a person’s karyotype, which, in addition to treating the person’s infertility, requires attention to the creation of abnormal gametes and considering preventive treatment measures for the person in question.

This surgeon and gynecologist said: Cystic fibrosis is a genetic disease that, like thalassemia, is passed from one generation to another by passing a recessive chromosome. If it affects a person, this disease can be one of the causes of male infertility, and with genetic counseling and diagnostic methods before implantation, like similar diseases such as thalassemia, the transmission of the disease to the next generation can be prevented.

Burgis emphasized: It is important to pay attention to the size of the testicles after puberty in males. By reducing its size, it is possible to reduce the number of germ cells in the testicles. If you feel any problem or delay in the emergence of secondary sexual characteristics (a problem that is important in both sexes), it is necessary to consult a doctor.

He said: Anatomical issues, including hypospadias, as well as the presence of endocrine diseases such as diabetes or thyroid problems in both sexes, also affect fertility.

By pointing out that about 40% of infertile men have varicocele, Burgess reminded: Varicocele can disrupt sperm production due to the creation of an environment that has a higher temperature than the ideal environment for sperm production. The use of saunas, hot tubs and spa pools due to high heat can also interfere with the sperm production process.

The risk of disrupting the process of spermatogenesis by taking bodybuilding drugs
This surgeon and gynecologist said: Taking some drugs, such as testosterone hormone compounds used in gyms, can disrupt sperm production and cause infertility in the long term.

Regarding other factors affecting male infertility, Burgess said: history of chemotherapy or use of certain drugs, history of radiation therapy or exposure to radiation affecting germ cells, childhood diseases including mumps, which after puberty leads to impaired sperm production, traumas In testicles, which is likely to occur and repeat in some athletes, infections such as gonorrhea and chlamydia can lead to blocked ducts and ultimately infertility in a person.

He reminded: One of the factors that congenitally creates the possibility of creating problems in the process of sperm production is hidden testicles or cryptovargidism, which if not detected and treated quickly at the time of birth, will lead to the damage of testicular germ cells and cause infertility and even permanent sterility. will be

Burgess said: One of the acquired causes of tubal obstruction in men is a history of previous vasectomy. In addition, some infections can lead to blocked ducts in men.

Occupational factors affecting infertility
This surgeon and gynecologist said: Environmental and occupational contacts, considering that men have more risky jobs and commit more risky behaviors, are more often discussed in the field of male infertility. Smoking and hookah are also harmful and should be strictly avoided.

He pointed out: Avoiding the consumption of any amount of alcohol, avoiding high-risk occupational contacts and controlling environmental conditions and being in high-risk environments, and avoiding skin and inhalation contact with a variety of toxic and harmful substances, including hydrocarbons and aromatic solvents that are used in oil paints. Glues and varnishes are used, radioactive substances, ethylene oxide, (ionizing and non-ionizing radiation in the pharmaceutical industry), agricultural poisons and pesticides, insecticides, solvents, vinyl chloride, copper, cadmium, mercury and heavy metals (in printing houses). and radiology) increase the risk of infertility.

In the end, Burgis clarified: In order to prevent infertility, one should avoid contact with industrial or organic solvents such as ethylene glycol in the dyeing and painting industry, contact with copper in the glazing industry and contact with chromium in the metal melting and welding industries, cadmium in the alloy production industry. , metal coating, solar cells, image lamp production and contact with lead in battery making, weapon making, pipe making, paint production, ceramics, etc. were avoided. The use of tight and plastic clothes and conditions that increase the temperature should also be seriously avoided.


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