Researchers believe that genetic elements that disrupt metabolism cause overweight. Researchers believe that this may be a way to predict whether a person will be overweight in the future. A new study has discovered 25 genetic elements associated with metabolic disorders that can lead to overweight.
The researchers’ discovery predicts a person’s risk of obesity and allows doctors to recommend lifestyle and dietary changes while the patient is still young.
The findings are widespread, with nearly 70 percent of adults 20 and older in the United States being overweight or obese, according to the Centers for Disease Control and Prevention (CDC).
While it is known that body fat increases the risk of diseases such as heart disease, diabetes and cancer, it is not understood what mechanisms are responsible for these diseases.
To better understand the underlying metabolic disorders of obesity, researchers examined the metabolic profiles of more than 2,000 people from the United States and England. Some of the participants were lean, others were obese.
The researchers collected data on the participants’ diet and lifestyle, blood pressure, and body mass index (BMI), a measure of body fat based on a person’s height and weight. They also took participants’ urine samples to measure substances. They analyzed the metabolite, which is obtained from the breakdown of food into energy.
Obesity risk factors have been identified
Study author Paul Elliott, professor of medicine at the School of Public Health at Imperial College London, said the biggest takeaway from the study is the understanding that obesity is a systemic disease and involves many different metabolic disorders that may be related to future risk of disease. be
Elliot said: This [مکانیسم] It may be a starting point for the development of new approaches to the prevention and treatment of obesity and related diseases.
Based on their analysis, Elliott and other researchers identified 25 metabolites that were strongly associated with BMI.
In obese subjects, the researchers discovered nine compounds produced by gut microbes that involved five different microbial metabolic pathways of the gut host, including those involved in the microbial breakdown of essential vitamins, amino acids, and protein.
Elliott said the results of this study showed that many interconnected systems in obesity [چربی بدن]including (metabolism of amino acids and body muscles, energy and intestinal bacterial metabolism) are involved.
Other metabolites detected were related to diet, including urinary glucose and a compound known to be a red meat marker associated with high BMI. In addition, an amino acid related to citrus consumption was associated with lower BMI.
Predictive markers of obesity risk
Researchers have created a map of metabolic networks that provide a big picture of the complex interactions between genetics, environment, diet and lifestyle that contribute to metabolic disorders in obesity.
The analysis of health care providers may inform patients at a young age of their risk of obesity and cause a person to prevent obesity in the future by modifying his diet and lifestyle earlier.
In the future, urinary metabolite patterns may be used to identify non-obese individuals with an increased risk of obesity and metabolic disease, Elliott said, adding that such individuals may benefit from personalized obesity prevention methods, for example, through modification. Lifestyle to improve diet and increase physical activity to prevent obesity.
Until then, Elliott notes that obesity is a major public health problem and is on the rise in many countries around the world.
Therefore, the efforts needed to prevent obesity through lifestyle modification including health, caution in diet and increasing physical activity should be intensified.
May 11, 1394 11:35
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