Chronic inflammatory demyelinating polyneuropathy is a type of neurological disease that damages and destroys the nerve in the body. The condition, abbreviated as CIDP, affects a person’s ability to move, especially the arms and legs, as well as their sensory functions, leading to burning and numbness.
According to the National Organization for Rare Disorders, this disease is a rare disorder and affects approximately 5 to 7 out of every 100,000 people in the United States.
1- Fast facts about CIDP:
– The average age of onset of the disease is 50 years old.
Men are twice as likely to get this disease than women.
– Symptoms may change with walking And walking, or burning and numbness in the hands and feet.
2- What are the causes of CIDP?
Although doctors do not know the exact cause CIDP They don’t know, but they believe that this disease is an autoimmune disorder in which the body’s defense system attacks healthy body tissues. about CIDP, the destruction of the healthy tissue of the myelin coating, which protects the nerves and enables the nervous system to transmit signals faster, causes it to occur. This condition causes inflammation in the nerves.
3- Its difference from other disorders
While this disease has similarities to other neurological disorders such as Guillain-Barre syndrome and multiple sclerosis (MS), it has several differences in onset, symptoms, and treatment.
For example, a person with GBS can often detect infections such as mononucleosis that occur before the onset of symptoms. People with CIDP They usually cannot remember a previous infection. A person with CIDP usually has symptoms that may last about 8 weeks, or twice as long as typical GBS symptoms. Another difference is that GBS is an acute disorder that usually won’t recur, while the symptoms CIDP It may continue. Some doctors consider CIDP to be a chronic form of GBS.
4- Signs
Symptoms associated with CIPD tends to progress. Some potential symptoms of this disease include:
– Clumsiness
– Dysphagia or difficulty in swallowing
– double vision
– Leg drop
– Loss of reflexes
– Falling asleep and numbness in hands or feet
Tingling or pain in the limbs
– Unwanted fatigue
Symptoms of the disease occur on both sides of the body, for example, in both legs. Some people may have only changes in sensory function, such as tingling and numbness, without changes in walking or movement.
5- What are the treatment options?
treatment CIDP It involves trying to reduce inflammation, which reduces nerve-related symptoms. Although there is no cure for this disease, medications that moderate or normalize the immune system can help improve the effects of CIDP on a person’s nerves.
The US Food and Drug Administration (FDA) recently approved two drugs for treatment CIDP has confirmed. Selected drugs reduce the activity of the immune system, which causes neurological symptoms. Both are in the IVIg (intravenous immunoglobulin) class.
One of these drugs is Gamunex and the other is Privigen. Both drugs contain antibodies (immunoglobulins) that help prevent other immunoglobulins from damaging the nerves.
While these drugs can reduce inflammation CIDP They help, but they don’t cure it. A doctor may also prescribe medications called immunosuppressants, which are known to suppress the immune system and improve the signs and symptoms of CIDP. These drugs include the following drugs:
Azathioprine – cyclophosphamide – cyclosporine – methotrexate – mycophenolate is another effective option for treatment. CIDP Plasma exchange or plasmapheresis. This procedure involves removing blood from a person and separating the red blood cells and their components, such as antibodies, from the plasma that interact with CIDP. Then the donor plasma is added to the blood again
transmitted to the individual.
Some medications can cause symptoms CIDP, help without reducing the immune system or reducing inflammation. These drugs can be given together with the immune system modulators mentioned above. They are:
Carbamazepine – Gabapentin – Amitriptyline – Perigabalin – Duloxetine
6- Diagnosis
Sickness CIDP It is a rare disease, so doctors may have difficulty diagnosing it at first. Because the symptoms are often progressive, the doctor may need to monitor and monitor the individual over a period of 1 to 2 months before making a definitive diagnosis.
A doctor will begin by taking a medical history and asking the patient about their symptoms. Some of the symptoms that may indicate CIDP include the absence of reflexes and weakness in the arms and legs.
7- Testing
After considering a person’s symptoms, the doctor will likely prescribe guidelines to avoid misdiagnosis for other similar disorders. For example, they may recommend a spinal tap to test the spinal fluid for the presence of inflammatory cells such as white blood cells. Meningitis and cancer The nervous system can also cause a wide range of symptoms similar to CIDP.
A doctor may also order tests to measure how well a person’s nerves conduct electrical signals. These tests include nerve conduction test and electromyography. If a person’s nerves are not functioning as fast as expected, this can be undiagnosed CIDP to support
Individuals respond differently to CIDP treatments. Some may see an improvement in immune system function, some may have many of their symptoms resolved, but some may experience no improvement at all.
8- Can diet help treat CIDP?
Doctors sometimes recommend an anti-inflammatory regimen for people with CIDP to help ease their symptoms. However, diet is not a substitute for the medications listed above. An anti-inflammatory diet has many of the same characteristics as healthy diets, so a person should avoid the following:
High sodium foods – High sugar foods – Processed foods – Saturated fats – Trans fats.
A person with CIDP should have a diet It should be more plant-based and full of colorful fruits and vegetables. Other foods that people with CIDP should eat include lean, lean meats and low-mercury fish such as salmon. Nutritional recommendations may vary based on an individual’s additional health conditions or unique dietary preferences.
9- Moving around
Those treated with CIDP Patients often experience improvement in symptoms and then a series of relapses. According to a study published in the journal “Neurological Surgical Treatment Options”, about 90% of people with CIDP receive suppressive treatments. Safety system The body will respond like IVIg. However, in the long term, many people with CIDP end up needing assistive devices such as canes, walkers, or wheelchairs to help them get around.
help. As a general rule, the earlier CIDP is diagnosed and treated for a person, the better their prognosis.
