What is pro keratosis? Causes, symptoms, ways to diagnose and treat it

What do you know about pro keratosis? Pro keratosis is a rare skin disease in which part of the skin is differentiated from other parts, the area around it changes color and the thickness of the skin in the center decreases. Factors that put people at risk for the disease include genetic inheritance, exposure to ultraviolet light, and suppression of the immune system. The five main types of the disease occur in different people depending on the person’s appearance, place of residence and age. Topical, oral, or surgical treatments can improve the disease together or separately, but they do not completely cure it. In this article from the section Sickness Dr. Salam’s review of pro keratosis and ways to treat it.

What is pro keratosis?

The name pro keratosis, which literally means scaling, originally refers to areas of the skin that are abnormally lesioned, formed from the scales of the sweat glands. We do not now know the cause of pro-keratosis and we know that this disease has nothing to do with skin pores. It is a rare skin disorder that affects the maturation of skin cells and causes lesions with distinct borders.

In this article, we will talk about the nature of different types of pro keratosis and how to treat them, but let’s first ask what causes and conditions exacerbate the disease. Adult skin cells harden with creatine accumulation during the keratinization process.

Pro keratosis is a disorder of the keratinization process that results in multiple lesions on the skin. Their center is thin, they are streaked and they have a definite border that can be made of creatine.

According to the Center (Genetic Information and Rare Diseases of the National Institutes of Health), pro keratosis is classified as a rare disease. This means that each type of disease affects less than 200,000 people in the United States.

What are the causes of pro keratosis?

Sometimes people develop pro keratosis after skin damage (such as burn wounds) or infections. The softer your skin is, the more at risk you are.

Although researchers still do not fully understand the root causes of pro-keratosis, they have identified key risk factors for people to develop the disease.

  • Hereditary and genetic: All types of pro keratosis can occur in family members, but sometimes a person with no family history becomes infected.
  • Exposure to ultraviolet light
  • Weak immune system: Lesions can be caused by the use of immunosuppressive therapies (eg, chemotherapy, radiation therapy, organ transplants) or a number of diseases (eg, AIDS, cancer, chronic kidney failure, Crohn’s, diabetes, disease). Liver) to progress.

How is this disease diagnosed?

Pro keratosis is usually diagnosed by its appearance. According to Carolina Chang, a dermatologist in East Greenwich, certain edges around the lesions can be seen well with the help of a dermatoscope (a polar skin magnifying glass).

Your doctor may also need a sample of the affected area for a biopsy. There are five main types of pro keratosis. And of course all types are rare, although the first two are more common than the others. You may get this disease more than once and experience a different type each time.

Pro keratosis

1. Superficial actinic pro keratosis (DSAP)

DSAP causes multiple lesions or patches that can make the skin red or brown. The lesions may grow up to half an inch in diameter.

Areas of skin that are exposed to the sun are often at risk, especially parts of the arms and legs, but these lesions may appear on a small percentage of people on the forehead and cheeks. In people with a rare form of the disease, the lesions may appear anywhere but on the hands and feet and show symptoms other than itching.

This condition usually occurs in adults in their 30s and 40s. It is twice as common in women as in men.

Causing factors

  • Hereditary and genetic, especially if it occurred in female relatives
  • Suppression of the immune system or exposure to UV light
  • These lesions often appear in the summer and heal in the winter, although exposure to the sun reduces the risk of non-actinic forms.
  • Less than 10 percent of people are at risk for benign cancer with the growth of cancer cells.

2. Pro keratosis classic pm

Initially, PM causes small brown lesions. These lesions become larger and hairless spots unchanged or slowly over the years. Typically, early adult lesions quickly turn into “giant picratosis” lesions 8 inches in diameter.

These lesions typically appear on specific organs of the body, but can also appear anywhere, including the hands, feet, neck, shoulders, face, genitals, and mucous membranes. This type usually shows no symptoms other than itching.

PM usually appears in childhood or adolescence. In some cases, there are pm lesions at birth. Men are twice as likely as women to have pm.

Factors affecting pm in adults include immunosuppression and UV exposure, although sometimes with trauma (Burn wounds) it is related.

Squamous cell or basal cell carcinoma can grow after pm cancer, but older people are more likely to have such an outcome.

3. Linear pukitratosis (LP)

LP is characterized by papules and plaques with a ring containing streaks of reddish-brown patches.

Numerous spots appear in the form of lines along the breasts or legs or on one side of the torso, head and neck. These spots, which can also cause itching or pain, may occur in one area (local) or several areas (public).

LP often appears in childhood or childhood, but sometimes occurs in adulthood. It is just as common in men as it is in women. People with a history of LP or DSAP in the family are more likely to get sick.

People with this type of skin have a higher risk of skin cancer or scamox than other types, although this is more likely in older people.

4. Porokeratosis Palmaris and Plantaris Disseminata (PPPD)

PPPD causes small, pale, and relatively uniform lesions on the soles of the feet and hands, but this condition may spread to other areas, including the mucous membranes. This type usually shows no symptoms other than itching.

PPPD appears at any age from birth to adulthood. Men are twice as likely as women to have this type of disease.


5. Pancreatic pukratosis

Numerous small tiny spots with thin margins usually appear on the palms of the hands and soles of the feet and in some cases cause itching or discomfort. These spots may spread slowly to other areas.

Mild pro keratosis usually appears in late childhood and may be associated with other types of pokeriotosis. It cannot be said that this disease is common in men or in women.

What are the complications of pro keratosis?

Most lesions due to pro keratosis are benign. In rare cases (about 7.5% of patients), basal cell carcinoma or squamous cell carcinoma – a type of skin cancer – may develop as a result of the disease. People who have large, linear lesions for a long time are at greater risk.

Dr. Klein from the Department of Dermatology in one of the US states that the risk of malignancy of these spots is very low.

How is it treated?

Many people can prevent malignancy just by protecting themselves from the sun and using moisturizers.

If you are worried about skin lesions, or have dry, itchy or sore skin, you may need to seek help from a dermatologist.

There are several treatments that can help, especially if you have small blemishes on your face, but doctors say these blemishes may come back.

Topical treatments

  • Fluorouracil: It can be effective for all types of the disease, but the lesions may recur.
  • Vitamin D3 analogues (eg, calypotriene, tacalcitol): May be effective in treating DSAP.
  • Retinoids (tretinoin, tazarotene): May reduce the appearance of blemishes and speed up the action of other topical treatments.
  • Diclofenac gel: can be effective for DSAP.
  • Imiquimod: May be effective in treating PM.
  • Calcinirin inhibitors (tacrolimus): May be effective in treating LP.

Oral treatment

Retinoids (isotretinoin, aitortin): Isotretinoin may be effective in treating DSAP and PPPD when combined with topical 5-fluorocorticillin; Aitortine may also be effective in treating LP.

Surgery and other treatments

  • Removal: A necessary procedure for malignant cases but not useful for multiple lesions.
  • Cold therapy: effective for treating DSAP and PPPD; It may also be used for small cancer cells.
  • Electrodessication and curettage: can be used to treat small lesions or curettage ineffective.
  • Laser Therapy: Different types of lasers are effective in treating DSAP, PM and LP.
  • Photodynamic therapy: effective for DSAP and LP types; It can be used to treat multiple lesions on a larger scale. It may also be used to treat small cancer cells.


Prevention of pro keratosis

Dr. Chang says that avoiding the sun is helpful in preventing all skin disorders, but reminds that people with the disease should be exposed to very little sun.

You can not change your hereditary and genetic data, but you can take steps to prevent the progression or recurrence of pukeratosis and reduce the risk of skin cancer. The US Academy of Dermatology offers the following tips to protect your skin from UV light:

  • Walk in the shade from 10 a.m. to 2 p.m.
  • Wear protective clothing such as hats and sunglasses
  • Even on cloudy days Sunscreens Use sunscreen 30 or higher, renew every two hours, after sweating and after swimming.
  • Avoid using a solarium
  • Check your skin regularly

If you notice a change in the pukiotratosis lesion of your skin, ask your doctor to speed up the process of assessing pukiotratosis.

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