What is unspecified primary cancer or CUP?

When doctors find cancer cells, they can tell which part of the body is affected first. This part can be a specific organ, a type of tissue, or a part of a person’s blood. If it is not clear, the person has a type of cancer, which is an unknown primary cancer.carcinoma of unknown primary Or in short CUP are called

This type of cancer is not known until it has spread to the person’s lymph nodes, liver, lungs, bones or skin. Although treatment may not work for this type of cancer, clinical trials may help.

1- The cause of primary cancer is unknown

Cancer occurs when a mutation occurs in a person’s DNA cells. The chemistry inside a person’s cell determines what behavior they have to control the cell. In most cases, many mutations occur before a cell becomes cancerous. Doctors believe that the DNA changes that cause CUP are not inherited, but happen during a person’s life; which may be due to a person’s exposure to unknown things that cause cancer, such as: radiation, chewing or smoking tobacco, or chemicals.

But these harmful changes also occur for unknown reasons. Many people with CUP are perfectly healthy, fit weight, often athletic and have good nutrition. If you or someone you know has suffered from this disease, you should note that there is nothing you could do to prevent it.

2- Uncertain early cancer symptoms

Depending on the location of the disease in the body, its symptoms are also different. Some symptoms include: swelling of the lymph nodes, mass in the abdomen, feeling of heaviness, pain in the chest or abdomen, shortness of breath, bone pain often in the back-buttock-legs, skin tumors, anemia (low amount of red blood cells), weakness, fatigue, loss of appetite, weight loss, changes in sleeping habits, Chronic coughhoarseness, nightmares, fever, bleeding or discharge.

Of course, there is also a chance that the person has no specific symptoms; Some people are diagnosed with CUP only after a test for other reasons.

3- Uncertain primary cancer diagnosis

Your doctor will order tests or ask you questions. They will also ask you about your history of health problems or any family history of cancer. Your blood, urine and stool samples can help your doctor get more information. Then the following tests are specific:

a- Imaging tests: Including X-ray, MRI, CT scan and so on sonography Is.

B- endoscopy: The doctor may send a very narrow tube into the body through the mouth, nose, or lower part of the person’s body, or make a small incision on the skin, and with the help of a small camera at the end of the tube, he can see the tumor more clearly. .

J- biopsy: Based on the type of tumor, the doctor takes a sample of its cells, liquid or bone marrow takes it and sends it to the laboratory, to take a closer look under the microscope. Recently, a new genetic test has been prepared that accurately identifies any part of the body where cancer has started to appear.

4- How is CUP treated?

most types of cancer,”Phase” are. These stages describe where they are in the body and how much they have spread. They also help prepare a treatment plan. Your doctor will decide how to treat you based on the location of the cancer, how the cells look under the microscope, your test results, your symptoms, and whether this is your first time or a recurrence.

Your treatment may include:

surgery: The doctor removes the cancerous part plus a part of the surrounding tissue.

Chemotherapy: You have to take very strong drugs that destroy cancer cells. These drugs may be intravenous or taken by mouth.

Radiotherapy: High power X-rays or other types of radiation can be used to destroy cancer cells. It may be inserted into your body by a machine or through a needle, wire, or a thin, sealed seed.

Hormone Therapy: If hormones are believed to be playing a role in your cancer, your doctor will try to reduce the amount in your body or maintain the type that is still useful. Sometimes this is done by drugs, but surgery and radiation therapy are also used at the same time.

Targeted therapy: Drugs or other supplements can attack cancer cells without affecting other parts of the body.

immunotherapy: This treatment is based on raising the body’s immune system in a general state or using an attack on cancer cells.

Clinical trials: In some cases, using clinical trials may be your best choice. These tests test a new drug for cancer and its treatment. These drugs may work as well or even better than conventional cancer treatments. CUP is different for each person. It is difficult to predict how it will be treated.

Make sure you discuss this fully with your doctor. Because he knows about your cancer, your test results and your overall health. In the end, he is the one who has a better opinion about restoring the chance of life in you.

Translated by: Sima Azadfalah

Rewriting: Farzaneh Pashaei

Any copying with the name of Dr. Salam and direct linking is allowed.

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